Topical Oxygen Is an Effective Treatment for Recalcitrant Ulcers

The findings of a new retrospective study suggest that topical oxygen is an effective treatment against recalcitrant wounds.

A new study finds that topical wound oxygen (TWO2) is an effective treatment for recalcitrant ulcers.
The study, "A Retrospective Review of Pressurized Cyclical Topical Oxygen as an Adjunct Treatment in Healing Chronic Wounds and Ulcerations," was a two-year retrospective review of the treatment of 71 patients at a Veterans Affairs hospital with 115 wounds between them. Each of the patients was prescribed at-home treatment with cyclical pressurized TWO2. The wound types included "a mix of venous/lymphatic insufficiency ulcers, surgical and traumatic wounds, diabetic ulcers, pressure ulcers and ischemic ulcers," according to a news release. "Additionally, most patients had concurrent peripheral vascular disease."

After two years, the researchers found that nearly two-thirds, 64.4 percent, of the 115 ulcers tracked for the study had completely closed and the majority of the remaining ulcers had decreased in size since beginning oxygen treatment. The study's authors also noted that "a number" of study subjects reported pain reduction associated with the oxygen treatment.

"We are delighted to see further scientific evidence supporting the effectiveness of our unique multi-modality TWO2 therapy in healing chronic ulcerations being presented at both the SAWC and EWMA conferences, which are the largest annual multi-disciplinary wound care conferences held in the USA and Europe respectively," said Mike Griffiths, CEO and president of AOTI, in a prepared statement. "AOTI remains committed to fostering the development of the strongest scientific evidence demonstrating both the healing and health economic benefits of our patented topical wound oxygen homecare therapy."

An abstract of the study is available at

About the Author

Joshua Bolkan is a freelance writer specializing in various markets including education and healthcare. He can be reached at


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